Speakers - PHWC2025

Abstract

Background

Chronic Kidney Disease (CKD) is one of the most rising non-communicable diseases nowadays. Besides some visible comorbidities, long-lasting urinary tract infections (UTIs) and their genetic predisposition become significant. So, the preventive perspective has been highlighted as a burning issue.

Method

From February 2023 to August 2023, 75 patients (females)with an age range of 35-47 years came with complaints of loin pain, low-grade fever, and lethargy (from the last 1-1.5 years) with no history of Diabetes or hypertension. 37 patients had a late voiding history, with the rest of the family history of UTI. Serum creatinine with eGFR, complete blood picture, and other investigations were given for further study and follow-up.

Result

After 1 month of follow-up, 45% of patients with creatinine were found in the range (of 1.8-3.5) mg/dl.35% of patients in (4-6.5)mg/dl; the rest found significant symptoms for hemodialysis to be relieved. 39% of patients in the above two groups had a history of late voiding with a positive family history of UTI. This group has been advised to start quick voiding as well as to maintain post-coital hygiene (for married women) for six months until follow-up. Dramatically, 33 patients’ creatinine levels fell (0.15- 1.37) % who had a history of both family evidence and late voiding. The creatinine level falls 0.09-0.75% in positive family history.

Conclusion

Though the rate of creatinine decrease in people with a positive family history of UTI is not satisfactory, its prevention is based upon early voiding habits. Screening for family history may be helpful in slowing the rate of progression of chronic kidney disease.

Keywords: creatinine, eGFR, UTI, genetic predisposition, hemodialysis