Northern Nigeria endures intense seasonal malaria transmission, with children under five facing heightened risk during peak rainy months, yet seasonal malaria chemoprevention (SMC) has emerged as a transformative intervention, reaching millions through expanding cycles and geographic coverage. Drawing on publicly available DHIS2-derived surveillance data and national programmatic reports from high-burden northwestern states (Kebbi, Sokoto, Zamfara), this analysis examines SMC deployment trends, coverage achievements, and associated reductions in uncomplicated malaria incidence amid scale-up from 2021–2025.
Leveraging 8+ years of expertise in USAID/PMI-supported malaria programs including mobilizing counterpart funding and overseeing commodity distribution across thousands of facilities the review highlights key enablers: high administrative coverage (often exceeding 80–90% per cycle in eligible areas), integration with routine immunization, and adaptive cycles (4–5 monthly doses of sulfadoxine-pyrimethamine + amodiaquine). Findings reveal variable but substantial declines in under-five malaria cases post-SMC expansion, with lower stock-out rates for preventive commodities and improved equity in rural access. Challenges persist in reporting completeness and last-mile delivery during peaks, underscoring needs for strengthened community engagement and digital surveillance.
This work advances public health innovation by demonstrating SMC’s role in resilient, evidence-based prevention, offering scalable models for sustainability and global health security in seasonal transmission zones across sub-Saharan Africa.