Intersectionality is recognized as a vital framework for analyzing and addressing how multiple, overlapping social identities and systems of power shape inequities and privilege. Based on a 4.5-year research project funded by the Canadian Institutes of Health Research (CIHR), this paper will present the findings from a variety of studies that were employed to collect information on the state of intersectionality-informed policy-relevant research and practice work internationally. These include two international workshops with researchers, community-based and NGO actors and policy actors from government and international organizations, textual critical analysis of existing guides, in-depth interviews with those who have developed guidance from around the world, and survey results from those who have engaged with the Intersectionality-Based Policy Analysis Framework (Hankivsky et. al. 2012) which is recognized as one of the most promising practices in operationalizing intersectionality. The results show what is required for the operationalization of intersectionality to fully reach its transformational potential for advancing equity and social justice in health policy.